The Papez circuit is a loop of connections described by James Papez in 1937: hippocampus, fornix, mammillary bodies, mammillothalamic tract, anterior thalamus, cingulate gyrus and back to the hippocampus via the cingulum and entorhinal cortex.
| Location | Medial surfaces of the cerebral hemispheres and diencephalon |
|---|---|
| Parts | |
| Connections |
|
| Blood Supply | Anterior, middle and posterior cerebral arteries; Anterior choroidal artery |
First proposed as a circuit for emotion, it is now understood mainly as a key circuit for forming episodic memories.
Damage at any point in the loop, such as the fornix after colloid cyst surgery, the mammillary bodies in Korsakoff syndrome or the anterior thalamus after stroke, can cause severe amnesia.
Thiamine deficiency damaging the mammillary bodies and thalamus, causing profound memory loss.
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