The entorhinal cortex lies on the front part of the parahippocampal gyrus, next to the uncus, roughly Brodmann area 28. It is the main gateway between the hippocampus and the rest of the cortex, sending the perforant path into the dentate gyrus and hippocampus. It contains grid cells, which help map position in space.
| Location | Anterior parahippocampal gyrus, medial temporal lobe, near the uncus |
|---|---|
| Parts |
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| Connections |
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| Blood Supply | Posterior cerebral artery; Anterior choroidal artery |
Passes information from the cortex into the hippocampus and back, supporting memory formation and spatial navigation.
The entorhinal cortex is usually the first cortical area to develop tau tangles in Alzheimer disease, before symptoms appear, which helps explain why memory for recent events fails first. Its thinning on MRI is an early marker of disease. It is also involved in temporal lobe epilepsy.
Early tau pathology and neuron loss in the entorhinal cortex disconnecting the hippocampus.
Memory problems beyond normal ageing, often with entorhinal thinning.
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