The limbic lobe is a ring of cortex on the medial surface of each hemisphere that encircles the corpus callosum and the top of the brainstem. It is made mainly of the cingulate gyrus above and the parahippocampal gyrus below, joined behind the splenium by the isthmus. The term comes from the Latin limbus, meaning border.
| Location | Medial surface of each hemisphere, forming a C-shaped ring around the corpus callosum |
|---|---|
| Parts | |
| Connections |
|
| Blood Supply | Anterior cerebral artery; Posterior cerebral artery |
Links emotion with memory and behaviour, and helps assign motivational value to experiences.
The limbic lobe forms the cortical core of the limbic system, so damage affects emotion, motivation and memory. The parahippocampal and entorhinal parts are among the first areas affected in Alzheimer disease. Lesions of the anterior cingulate can cause apathy and, when on both sides, akinetic mutism.
Inflammation of limbic structures, often autoimmune or paraneoplastic, causing memory loss, seizures and psychiatric change.
Neurodegeneration beginning in the entorhinal and parahippocampal cortex and spreading to other cortical areas.
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