The zona reticularis is the innermost layer of the adrenal cortex, next to the medulla, made of a network of cell cords. It produces adrenal androgens, chiefly DHEA and its sulphate, plus some cortisol, and it becomes active around age 6-8 in a process called adrenarche.
| Location | Innermost zone of the adrenal cortex, bordering the adrenal medulla |
|---|---|
| Secretes |
|
| Blood Supply | Cortical sinusoids from the subcapsular plexus |
Produces weak androgens that are converted in tissues to testosterone and oestrogens, contributing to body hair and libido, especially in women.
Adrenal androgens contribute to pubic and armpit hair, particularly in women. Excess adrenal androgen from congenital adrenal hyperplasia or an androgen-secreting tumour causes virilisation in girls and women and early puberty in children. DHEA-S levels help distinguish adrenal from ovarian sources of excess androgen.
Early rise in adrenal androgens in childhood causing early pubic hair and body odour, usually benign but needing evaluation.
A rare tumour producing excess DHEA and other androgens, causing rapid virilisation.
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