The stratum granulosum is a thin layer of 1-5 cell rows where keratinocytes flatten, fill with dark granules and release lipids. Here the cells begin to die and form the skin waterproof barrier.
| Location | Between the stratum spinosum below and the stratum lucidum or corneum above |
|---|---|
| Parts |
|
| Nerve Supply | Free nerve endings and Merkel cells from cutaneous nerves |
| Blood Supply | None (epidermis is avascular; nourished from dermal capillaries) |
| Venous drainage |
|
| Lymphatic drainage |
|
Produces the lipid seal and keratin proteins that form the main water barrier of the skin.
Faulty filaggrin, made in this layer, is a major genetic risk for eczema and dry skin (ichthyosis vulgaris). The layer is thin or absent in psoriasis.
Inherited dry scaly skin linked to reduced filaggrin and keratohyalin granules.
Itchy inflamed skin with a weakened barrier, often linked to filaggrin defects.
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