The medulla is the inner part of a lymph node, made of medullary cords of plasma cells and macrophages separated by medullary sinuses that lead to the efferent vessel at the hilum.
| Location | Centre of the lymph node, near the hilum |
|---|---|
| Blood Supply | Branches of the nodal artery |
| Venous drainage |
|
| Lymphatic drainage |
|
Plasma cells here release antibodies into lymph, and macrophages filter lymph before it leaves the node.
Cancer cells arrive through the afferent vessels and sinuses before invading the node. Macrophage-laden sinuses are prominent in nodes draining areas of inflammation or tattoo pigment.
Accumulation of macrophages in nodal sinuses, usually a reactive change.
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