The transformation zone is the ring of tissue on the cervix where the glandular lining of the canal is replaced over time by squamous lining like that of the vagina. Its position moves with age, pregnancy and hormones.
| Location | Around the external os of the cervix; more outward in young women and pregnancy, inside the canal after menopause |
|---|---|
| Parts |
|
| Nerve Supply | Uterovaginal plexus (inferior hypogastric plexus) |
| Blood Supply | Uterine artery |
| Venous drainage |
|
| Lymphatic drainage |
|
An area of normal cell change from glandular to squamous lining.
Almost all cervical cancers start here, usually driven by persistent HPV infection. Cervical screening samples cells from this zone, and colposcopy examines it closely. Treatment of precancer removes the zone (for example by LLETZ).
Precancerous change in the transformation zone detected by screening.
Cancer usually caused by high-risk HPV, arising in the transformation zone.
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