The L5-S1 disc is the most highly loaded lumbar disc, accepting the greatest mechanical stress from the combination of lumbar lordosis and sacral kyphosis. The S1 nerve root is compressed by L5-S1 posterolateral disc herniation, producing pain radiating to the posterior thigh and leg, heel numbness, and plantarflexion weakness. L5-S1 spondylolisthesis (forward slip of L5 on S1) occurs at this level from pars interarticularis defects.
L5-S1 herniation compresses S1, producing absent ankle reflex, plantar foot and posterior leg pain, and gastrocnemius-soleus weakness (single-leg heel rise failure). Isthmic spondylolisthesis from bilateral pars defects allows L5 to slip forward on S1, producing buttock and posterior thigh pain with L5 radiculopathy from the foraminal L5 nerve root compression.
S1 root compression producing absent ankle reflex and posterior leg pain managed with conservative care or microdiscectomy for neurological deficit.
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