The interosseous membrane space of the leg is the anatomical corridor between the tibia and fibula occupied by the interosseous membrane and traversed by the anterior tibial artery and deep peroneal nerve anteriorly and the perforating branch of the peroneal artery posteriorly. This space is functionally distinct from the anterior and posterior compartments it separates.
The anterior tibial artery passes through an opening in the superior interosseous membrane to reach the anterior compartment. This passage is a recognised site of vessel compression in high anterior compartment pressure. Fibular free flap harvest preserves the interosseous membrane space to maintain tibiofibular stability. The space is assessed during tibiofibular diastasis repair to ensure correct syndesmotic reduction.
Blood collection in the interosseous membrane space from tibial or fibular fracture producing pressure on the anterior tibial artery at its membrane passage and contributing to anterior compartment syndrome.
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