The greater sciatic foramen is the large opening between the greater sciatic notch of the ilium and the sacrospinous ligament, through which the piriformis muscle passes and the major neurovascular structures exit the pelvis: the sciatic nerve, superior and inferior gluteal vessels and nerves, pudendal nerve, internal pudendal vessels, nerve to obturator internus, and the posterior femoral cutaneous nerve.
The greater sciatic foramen is divided by the piriformis into the suprapiriform and infrapiriform spaces. The sciatic nerve exits infrapiriformly in 84% of individuals. Foramen contents are compressed in piriformis syndrome, gluteal compartment syndrome, and sacral fractures with posterior displacement. CT-guided approaches to the sciatic notch are used for sciatica nerve hydrodissection and posterior hip denervation procedures.
Sciatic nerve compression in the infrapiriform space of the greater sciatic foramen by a hypertrophied or fibrotic piriformis, producing deep gluteal pain and sciatica that worsens with hip external rotation.
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