Leydig (interstitial) cells lie in the connective tissue between the seminiferous tubules of the testis. They produce about 95% of male testosterone in response to luteinising hormone.
| Location | Interstitial tissue between seminiferous tubules in the testis |
|---|---|
| Secretes |
|
| Nerve Supply | Testicular plexus |
| Blood Supply | Testicular artery |
| Venous drainage |
|
| Lymphatic drainage |
|
Make testosterone, which drives sperm production, male sexual development, muscle and bone mass and libido.
Anabolic steroid use suppresses LH and shuts down Leydig cell testosterone production, shrinking the testes and reducing fertility, sometimes for a long time after stopping. Rare Leydig cell tumours can cause early puberty or breast enlargement.
Low testosterone from Leydig cell failure or reduced LH stimulation.
Suppressed testosterone production and testicular shrinkage after steroid use.
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