The septum pellucidum is a thin, two-layered vertical sheet that separates the front parts of the right and left lateral ventricles. It stretches from the underside of the corpus callosum down to the fornix.
| Location | Midline, between the frontal horns and bodies of the lateral ventricles, below the corpus callosum and above the fornix |
|---|---|
| Parts |
|
| Connections | |
| Blood Supply | Anterior cerebral artery (septal branches); Anterior communicating artery perforators |
Acts as a partition between the lateral ventricles and carries some fibres linking the hippocampus and septal area.
A small fluid gap between its layers (cavum septi pellucidi) is normal in newborns and often persists harmlessly, but a large persistent cavum is more common in boxers and others with repeated head impacts. Absence of the septum occurs in septo-optic dysplasia, with poor vision and pituitary problems. Shift of the septum on scans shows midline shift from a mass or bleed.
Developmental absence of the septum with underdeveloped optic nerves and pituitary hormone deficiency.
A fluid space between the layers, usually a normal variant, more common after repetitive head trauma.
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