The gonadal veins drain the testes and ovaries with important anatomical asymmetry: the right gonadal vein drains directly into the inferior vena cava at an acute angle, while the longer left gonadal vein drains into the left renal vein at a right angle before that vein joins the IVC. This asymmetry makes venous return from the left gonad less efficient and explains the preponderance of left-sided varicocele.
Left-sided varicocele (dilated tortuous left pampiniform plexus) occurs predominantly on the left because the left gonadal vein drains into the left renal vein at a right angle, creating relatively higher venous pressure. Varicoceles are associated with male subfertility and testicular pain. Embolisation or surgical ligation of the left gonadal vein treats the varicocele. A new left-sided varicocele in a middle-aged man may indicate renal cell carcinoma occluding the left renal vein (secondary varicocele). The right gonadal vein joins the IVC and rarely produces varicocele.
Dilatation of the pampiniform plexus draining via the gonadal vein, predominantly left-sided due to the perpendicular left renal vein drainage, produces a bag of worms sensation in the scrotum, impairs spermatogenesis by elevating testicular temperature, and is treated by embolisation or surgical ligation.
A new right-sided varicocele or a varicocele that fails to empty in the supine position suggests renal cell carcinoma invading the renal vein and occluding gonadal vein drainage, requiring urgent renal ultrasound and CT to exclude malignancy.
This website uses cookies to enhance your experience. Some are essential for site functionality, while others help us analyze and improve your usage experience. Please review your options and make your choice.
If you are under 16 years old, please ensure that you have received consent from your parent or guardian for any non-essential cookies.
Your privacy is important to us. You can adjust your cookie settings at any time. For more information about how we use data, please read our privacy policy. You may change your preferences at any time by clicking on the settings button below.
Note that if you choose to disable some types of cookies, it may impact your experience of the site and the services we are able to offer.
Some required resources have been blocked, which can affect third-party services and may cause the site to not function properly.
This website uses cookies to enhance your browsing experience and ensure the site functions properly. By continuing to use this site, you acknowledge and accept our use of cookies.