The cephalic vein arises from the dorsal venous network of the hand, ascends along the radial border of the forearm, crosses the antecubital fossa to reach the lateral bicipital groove, continues along the lateral arm, and pierces the deltopectoral fascia to drain into the axillary vein at the deltopectoral groove. It is consistently accessible and large throughout its course.
The cephalic vein is a preferred site for venous access, blood sampling, and peripheral IV placement throughout the forearm. It is the vessel of choice for creating a brachiocephalic arteriovenous fistula at the wrist (radiocephalic, Brescia-Cimino fistula) or elbow (brachiocephalic fistula) for haemodialysis access. During pacemaker and defibrillator implantation, the cephalic vein in the deltopectoral groove is the primary vessel used for lead insertion before subclavian puncture is considered.
Superficial thrombophlebitis from IV cannula placement or adjacent infection produces a tender, indurated, erythematous cord along the cephalic vein, treated with NSAIDs, warm compresses, and limb elevation; extension to the axillary vein requires anticoagulation.
Stenosis at the junction of the cephalic vein and axillary vein in haemodialysis patients causes access dysfunction with high venous pressures and poor flows, treated by percutaneous balloon angioplasty or surgical revision.
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