The lateral superior genicular nerve is an articular branch of the common peroneal nerve supplying the lateral and anterolateral knee capsule at the level of the lateral femoral condyle. It is one of the primary targets for knee genicular nerve ablation alongside the medial superior and medial inferior genicular nerves.
The lateral superior genicular nerve courses along the lateral femoral condyle and is consistently ablated in the three-nerve protocol for genicular radiofrequency ablation used to treat knee osteoarthritis pain. Its anatomical position at the superomedial femoral condyle is identified under fluoroscopy for accurate probe placement. It is at risk during lateral knee arthroscopic portal placement.
Inadvertent injury to the lateral superior genicular nerve from lateral knee portal placement producing lateral knee numbness and pain, identified by diagnostic block and managed conservatively.
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