The corneoscleral junction (limbus) ligament is the fibrous transition zone between the transparent corneal stroma and the opaque sclera, providing the structural continuity of the anterior ocular wall at this critical biomechanical junction.
Provides the structural continuity between cornea and sclera, is the zone of stem cells for corneal epithelial renewal, contains Schlemm's canal and the trabecular meshwork for aqueous humour outflow, and is the attachment zone for conjunctival and Tenon's capsule.
The limbal region contains the corneal stem cells — limbal stem cell deficiency from chemical burns, Stevens-Johnson syndrome, or aniridia produces corneal vascularisation and opacity. Limbal stem cell transplantation restores the corneoscleral junction integrity and corneal clarity.
Destruction of the corneoscleral junction stem cell zone by chemical burns or immune conditions producing corneal vascularisation and blindness, treated by limbal stem cell allograft transplantation.
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