The uncinate fasciculus is a hook-shaped association bundle that curves around the stem of the lateral sulcus to connect the anterior temporal lobe and amygdala with the orbitofrontal and inferior frontal cortex. It is among the last tracts to mature, continuing into the third decade. It links emotion and memory with decision making.
| Location | Deep to the limen insulae, hooking between the anterior temporal lobe and the inferior frontal lobe |
|---|---|
| Connections | |
| Blood Supply | Middle cerebral artery (deep branches) |
Links the anterior temporal lobe and amygdala with the orbitofrontal cortex, supporting emotional memory, social behaviour and naming.
Changes in the uncinate fasciculus are reported in frontotemporal dementia, psychopathy, anxiety and mood disorders. It is often affected in temporal lobe surgery and in traumatic brain injury. Left-sided damage can impair naming of objects and people.
Degeneration involving the uncinate fasciculus, linked to emotional and social behaviour change.
Frontotemporal injury that may damage the uncinate fasciculus and affect behaviour and memory.
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