The subiculum is a strip of cortex that forms the transition zone between the hippocampus proper and the entorhinal cortex in the medial temporal lobe. It is the main output region of the hippocampal formation.
| Location | Medial temporal lobe, between the CA1 field of the hippocampus and the entorhinal cortex on the parahippocampal gyrus |
|---|---|
| Parts |
|
| Connections | |
| Blood Supply | Posterior cerebral artery (hippocampal branches); Anterior choroidal artery |
Sends processed hippocampal output to the fornix and cortex; important for memory, spatial navigation and stress responses.
The subiculum is affected early in Alzheimer disease and can be a source of seizure activity in temporal lobe epilepsy. Its shrinkage can be measured on research MRI.
Early loss of neurons in the subiculum and neighbouring regions causes memory decline.
Seizures arising from the hippocampal formation including the subiculum.
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