The organum vasculosum of the lamina terminalis is a small circumventricular organ in the front wall of the third ventricle. It contains sensors that detect blood salt concentration and circulating fever signals.
| Location | Lamina terminalis, front wall of the third ventricle, above the optic chiasm |
|---|---|
| Parts |
|
| Connections |
|
| Blood Supply | Anterior cerebral and anterior communicating artery branches |
Detects rising blood saltiness to drive thirst and vasopressin release, and helps trigger fever in response to inflammatory signals.
It is one of the main brain sites where circulating cytokines trigger prostaglandin production and fever; drugs such as aspirin and ibuprofen reduce fever partly by blocking this. Disturbed osmosensing contributes to sodium disorders.
A raised temperature set point triggered by inflammatory signals sensed in this area and nearby hypothalamus.
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