The medial forebrain bundle is a loose two-way bundle of fibres passing through the lateral hypothalamus. It links the basal forebrain with the midbrain and carries the dopamine, noradrenaline and serotonin pathways that ascend to the forebrain.
| Location | Lateral hypothalamus, from the basal forebrain to the midbrain tegmentum |
|---|---|
| Parts |
|
| Connections | |
| Blood Supply | Anterior and posterior communicating artery perforators |
Major route for reward, motivation and arousal signals.
In classic experiments animals worked hard to stimulate it, revealing reward circuits. Deep brain stimulation of its upper part is being investigated for severe depression.
Severe depression for which medial forebrain bundle stimulation has been explored.
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