The interposed nuclei are two small deep cerebellar nuclei, the emboliform and globose nuclei, lying between the dentate and fastigial nuclei. They receive output from the intermediate (paravermal) zone of the cerebellum and help correct limb movements while they are happening.
| Location | Deep cerebellar white matter, between the dentate nucleus laterally and the fastigial nucleus medially, above the fourth ventricle |
|---|---|
| Parts |
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| Connections |
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| Blood Supply | Superior cerebellar artery |
Compare intended movements with feedback from the limbs and adjust ongoing limb movement through the rubrospinal and corticospinal systems.
Lesions of the interposed nuclei contribute to ipsilateral limb ataxia and tremor. In humans they are rarely damaged in isolation, but they are involved in cerebellar strokes and tumours of the deep cerebellar region. In experimental animals they are essential for conditioned eyeblink learning.
Poorly controlled, oscillating limb movements from damage to the interposed nuclei or their outflow.
Infarction or haemorrhage involving the deep nuclei, causing ipsilateral ataxia and dysarthria.
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