The globus pallidus is the paler, inner part of the lentiform nucleus, lying medial to the putamen and lateral to the internal capsule. It is divided into an external segment and an internal segment. The internal segment is the main output nucleus of the basal ganglia, sending inhibitory signals to the thalamus.
| Location | Medial part of the lentiform nucleus, between the putamen and the internal capsule |
|---|---|
| Parts |
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| Connections |
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| Blood Supply | Lenticulostriate arteries; Anterior choroidal artery |
Regulates movement by sending inhibitory output to the thalamus, holding back unwanted movements while letting selected ones through.
The globus pallidus internus is a deep brain stimulation target for Parkinson disease and dystonia, and was the site of pallidotomy before stimulation was available. It is vulnerable to carbon monoxide poisoning and, on MRI, shows changes in manganese and iron accumulation disorders. Lesions can cause parkinsonism or dystonia.
Characteristic bilateral pallidal damage causing parkinsonism and cognitive problems.
Sustained abnormal muscle contractions that may respond to deep brain stimulation of the globus pallidus internus.
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