The dorsolateral prefrontal cortex covers the lateral parts of the superior and middle frontal gyri, mainly Brodmann areas 9 and 46. It is the brain's main workspace for holding and manipulating information over short periods. It is closely linked with the parietal cortex and caudate nucleus.
| Location | Lateral surface of the frontal lobe, mainly the middle frontal gyrus and adjacent superior frontal gyrus |
|---|---|
| Parts |
|
| Connections | |
| Blood Supply | Middle cerebral artery; Anterior cerebral artery (upper part) |
Holds and manipulates information in working memory and supports planning, reasoning, attention and flexible goal-directed behaviour.
Damage impairs working memory, planning, flexible thinking and the ability to switch strategies, as tested by the Wisconsin card sorting task. Reduced activity here is described in depression and schizophrenia. Left dorsolateral prefrontal cortex is the standard target for repetitive transcranial magnetic stimulation in treatment-resistant depression.
Depression that may respond to transcranial magnetic stimulation targeted at the left dorsolateral prefrontal cortex.
Poor working memory, planning and cognitive flexibility after dorsolateral damage.
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