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Home › Body Atlas › Sense Organs › Corneal Stroma
Sense Organ Head & Skull

Corneal Stroma

substantia propria corneae

The corneal stroma makes up about 90% of the cornea thickness. It consists of about 200 regularly stacked layers of collagen fibrils with flat cells between them, an arrangement that keeps it transparent.

Anatomical Data

Structure & Supply

LocationMiddle layer of the cornea, between Bowman layer and Descemet membrane
Parts
  • Collagen lamellae
  • Keratocytes
  • Proteoglycan ground substance
Nerve SupplyLong and short ciliary nerves (ophthalmic nerve, trigeminal)
Blood SupplyNone (avascular; nourished by tears, aqueous humour and limbal vessels)
Biomechanics

Function & Actions

Provides strength and transparency and does most of the cornea focusing work together with its curvature.

Clinical Relevance

Clinical Notes

Swelling of the stroma makes the cornea cloudy. LASIK reshapes the stroma under a flap. Corneal cross-linking strengthens the stroma to halt keratoconus, and corneal transplants replace damaged stroma.

Pathology

Common Injuries & Conditions

Corneal Oedema

Swelling of the stroma causing cloudy vision, often from endothelial failure.

Infectious Keratitis

Infection of the cornea, often linked to contact lenses, that can scar the stroma.

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