The paracortex is the deep cortex of a lymph node, between the follicles and the medulla. It is the T cell zone, where dendritic cells present antigens to T cells.
| Location | Between the outer cortex (follicles) and the medulla of each lymph node |
|---|---|
| Blood Supply | Branches of the nodal artery |
| Venous drainage |
|
| Lymphatic drainage |
|
Activates T cells, which then help B cells and leave to fight infection.
Lymphocytes enter nodes through specialised high endothelial venules here. The paracortex expands in viral infections and some drug reactions. It is depleted in some immunodeficiencies such as DiGeorge syndrome.
T zone expansion in viral infections such as glandular fever.
Absent or small thymus with few T cells, leaving the paracortex sparse.
This website uses cookies to enhance your experience. Some are essential for site functionality, while others help us analyze and improve your usage experience. Please review your options and make your choice.
If you are under 16 years old, please ensure that you have received consent from your parent or guardian for any non-essential cookies.
Your privacy is important to us. You can adjust your cookie settings at any time. For more information about how we use data, please read our privacy policy. You may change your preferences at any time by clicking on the settings button below.
Note that if you choose to disable some types of cookies, it may impact your experience of the site and the services we are able to offer.
Some required resources have been blocked, which can affect third-party services and may cause the site to not function properly.
This website uses cookies to enhance your browsing experience and ensure the site functions properly. By continuing to use this site, you acknowledge and accept our use of cookies.
