Lymphoid follicles are rounded clusters of B cells found in lymph nodes, spleen, tonsils and mucosal lymphoid tissue. When activated by an infection they develop a pale germinal centre where B cells multiply and refine their antibodies.
| Location | Outer cortex of lymph nodes; white pulp of the spleen; tonsils; Peyer patches; MALT |
|---|---|
| Blood Supply | Local supplying arteries of the host organ |
| Venous drainage |
|
| Lymphatic drainage |
|
Generate high-affinity antibodies and memory B cells.
Follicles enlarge during infection, causing swollen nodes. Follicular lymphoma, a common slow-growing lymphoma, mimics the pattern of follicles. Vaccines work largely by triggering germinal centre reactions.
Benign enlargement of nodes from infection or inflammation.
A slow-growing B cell lymphoma that grows in a follicle-like pattern.
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