The tuberomammillary nucleus is a small group of neurons in the back of the hypothalamus near the mammillary bodies. It is the only source of histamine-releasing neurons in the brain.
| Location | Posterior hypothalamus, around the mammillary bodies and near the base of the brain |
|---|---|
| Parts |
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| Connections |
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| Blood Supply | Posterior communicating and posterior cerebral artery perforators |
Promotes wakefulness and alertness through widespread histamine release.
Older antihistamines cross into the brain and block this system, causing drowsiness, which is why they are used in sleep aids and why they impair driving and sport performance. Newer antihistamines largely avoid this.
Drowsiness and slowed reactions from drugs blocking brain histamine signalling.
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