The middle cerebellar peduncle is the largest of the three cerebellar peduncles, a thick band of white matter connecting the pons to the cerebellum. It carries input only, made of pontocerebellar fibres from the opposite pontine nuclei, which relay information from the cerebral cortex.
| Location | Lateral to the pons, sweeping backward from the basilar pons into each cerebellar hemisphere, lateral to the other two peduncles |
|---|---|
| Parts |
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| Connections |
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| Blood Supply | Anterior inferior cerebellar artery; Superior cerebellar artery; Basilar artery circumferential branches |
Conveys movement plans and cortical information from the cerebral cortex via the pons to the cerebellum.
A lesion of the middle cerebellar peduncle causes ipsilateral limb ataxia. The MCP sign, bright signal in both peduncles on MRI, is seen in fragile X-associated tremor ataxia syndrome, and MCP atrophy occurs in the cerebellar form of multiple system atrophy. Demyelination and AICA strokes may also affect it.
A late-onset disorder in carriers of a fragile X premutation, with tremor, ataxia and characteristic MRI signal changes in the middle cerebellar peduncles.
A stroke in the AICA territory affecting the peduncle, causing vertigo and ipsilateral ataxia.
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