The genu is the thick, knee-shaped bend at the front of the corpus callosum. Its fibres curve forwards into the frontal lobes on both sides, forming a U-shaped bundle called the forceps minor. It forms the front wall of the frontal horns of the lateral ventricles.
| Location | Anterior bend of the corpus callosum, in front of the septum pellucidum |
|---|---|
| Parts |
|
| Connections |
|
| Blood Supply | Anterior cerebral artery (pericallosal artery) |
Connects the prefrontal cortices of the two hemispheres.
Lesions here may contribute to problems with attention and executive function by disconnecting the prefrontal cortices. The genu is a common site for multiple sclerosis plaques and is affected in Marchiafava-Bignami disease, a rare callosal degeneration in chronic alcohol use. Diffusion imaging of the genu is used in research on ageing and psychiatric conditions.
Rare demyelination and necrosis of the corpus callosum, usually in severe chronic alcohol use.
Demyelinating lesion that often involves the corpus callosum, including the genu.
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