The anterior commissure is a small, compact bundle of fibres that crosses the midline in the front wall of the third ventricle, just below the rostrum of the corpus callosum. It connects the anterior temporal lobes, including the amygdala, and parts of the olfactory system. It is shaped like the handlebars of a bicycle.
| Location | Anterior wall of the third ventricle within the lamina terminalis, in front of the columns of the fornix |
|---|---|
| Parts |
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| Connections |
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| Blood Supply | Anterior cerebral artery (perforating branches); Anterior communicating artery (perforating branches) |
Connects the anterior temporal lobes and olfactory regions of the two hemispheres.
The anterior commissure and posterior commissure define the standard reference line (AC-PC line) used to align brain images and plan stereotactic surgery. It may provide a backup route between the temporal lobes when the corpus callosum is absent or cut. It lies in the lamina terminalis, a landmark in surgery of the third ventricle.
In absence of the corpus callosum, the anterior commissure may be enlarged and carry some interhemispheric traffic.
Tumours of the anterior third ventricle region that may displace the anterior commissure.
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